Does GARP really fail miserably? A response to )

The Pill Really Can Be Mightier Than the Sword: A Response to Recent Commentaries

We appreciate the four commentaries that add new material and fresh perspectives to our article “The pill is mightier than the sword.” In emphasizing the role of voluntary family planning and girls’ education as achievable strategies with a potential to make the world a more peaceable place, we did not mean to oversimplify or disregard the intrinsic complexity of human conflict. On the whole, t...

When Does Weighted A* Fail?

Weighted A* is the most popular satisficing algorithm for heuristic search. Although there is no formal guarantee that increasing the weight on the heuristic cost-to-go estimate will decrease search time, it is commonly assumed that increasing the weight leads to faster searches, and that greedy search will provide the fastest search of all. As we show, however, in some domains, increasing the ...

Does a tradeoff really exist?

Does Age (Really) Matter? A Response to Manning, Carroll, and Carp

For some months now, we have been at work on a project called ‘‘Grouping Data.’’ In it, we address several specific questions (e.g., Under what circumstances should we group data? If the appropriate circumstances exist, how ought we proceed?). But our overarching message is a simple one: the decisions we make over how to group data may crucially affect the inferences we reach. This certainly ho...

Does MDR-1 G2677T/A polymorphism really associate with ovarian cancer response to paclitaxel chemotherapy?

To the Editor: In the February 1, 2006 issue of Clinical Cancer Research , Gréen et al. (1) described an association between G2677A/T single nucleotide polymorphism of MDR-1 gene and response to paclitaxel chemotherapy. The investigators state that ‘‘the probability of responding to paclitaxel treatment is higher in homozygously mutated patients (TT or TA)’’. In our opinion, there are some issu...